The Arizona Cardinals announced a flurry of roster moves on Saturday to prepare for their game on Sunday against the San Francisco 49ers. They placed linebacker Mack Wilson, who missed one game already with a rib injury, on injured reserve, which puts him out of commission for at least four more games.

Get our best 49ers vs. Cardinals predictions ahead of Sunday's showdown in Glendale. Free NFL picks for November 16, 2025.

The 49ers couldn’t ask for a better matchup on both sides of the ball. Offensively, the 49ers face a defense that is 21st in passing efficiency and 25th in pressure rate. It’s also a defense that’s middle of the pack at stopping the run.

The Niners are missing Nick Bosa, Fred Warner, Brandon Aiyuk, and seemingly countless others. The Cardinals will suit up without Marvin Harrison Jr. and Will Johnson. It sets this game up to be gritty and emotional, but both teams still have plenty of good players and Pro Bowl talents.

The 49ers have six players on their report with injuries, and five have no game status designation while fully practicing Friday. Only starting cornerback Deommodore Lenoir is questionable. He was added to the report as limited Thursday with a calf injury suffered in practice and did not practice Friday.

Mac Jones filled in well as the 49ers' starting quarterback while Brock Pirdy has been out, but now he's headed back to the bench.

The San Francisco 49ers have needed a lot of depth pieces on their roster to step up with all of the injuries surrounding the team. However, a few players have

In a 34-24 victory over the New York Giants on Nov. 2, Robinson bowled over cornerback Deonte Banks on an 18-yard touchdown run. In a 42-26 loss to the Los Angeles Rams on Nov. 9, Robinson smashed through a tackle attempt by inside linebacker Nate Landman on a 1-yard touchdown run.