Their first high-stakes meeting came in the 2021 Sweet 16, where Bueckers led UConn with 18 points, nine rebounds and eight assists in a 92–72 win over Iowa.

Clark was named an All-Star captain, garnering the most fan votes of the All-Star starters, which were decided by 50% fan vote, 25% media vote, and 25% player vote.

Golden State went on a run to end the first half and held a 41-32 advantage at halftime.