The Niners are missing Nick Bosa, Fred Warner, Brandon Aiyuk, and seemingly countless others. The Cardinals will suit up without Marvin Harrison Jr. and Will Johnson. It sets this game up to be gritty and emotional, but both teams still have plenty of good players and Pro Bowl talents.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday, Nov. 16, 2025 at State Farm Stadium in Glendale, Arizona.

Without their explosive rookie receiver, the Cardinals' offense faces a significant challenge. The 49ers' battered defense could exploit this crucial void.

A r ecent report from Ian Rapaport of NFL Network noted that the 49ers may be willing to entertain trade offers for Jones. Jones is on a modest contract heading into next year with a cap hit just under $4M. It gives the 49ers a lot of leverage.

The San Francisco 49ers on Thursday had a true rarity to open the day's practice. ESPN's Nick Wagoner reported every member of the 49ers' active roster was on hand to open the session. That is a dramatic change for a 49ers club that has been battling major injury issues since training camp.

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

The 49er defense is reeling with all the injuries. 30th in success rate since Warner’s injury, last in pressure rate for the year, tied for last in sacks. If they can stop anyone, it’s this depleted Arizona offense. If they can’t, then the Niners won’t be able to stop anybody, and that’s a primary concern for the rest of the season.

In a 34-24 victory over the New York Giants on Nov. 2, Robinson bowled over cornerback Deonte Banks on an 18-yard touchdown run. In a 42-26 loss to the Los Angeles Rams on Nov. 9, Robinson smashed through a tackle attempt by inside linebacker Nate Landman on a 1-yard touchdown run.